Results of a study of the quality of life in patients with highly active multiple sclerosis in Russia

Multiple sclerosis (MS) is a chronic autoimmune inflammatory demyelinating and neurodegenerative disease of the central nervous system. Now 2.8 million people in world suffer from MS, since 2000 every 5 years there has been an increase number MS patients by 10%. At same time, cases with highly active (HAMS) increasing, i.e. two or more exacerbations without taking specific pathogenetic therapy one exacerbation during disease-modifying therapies (DMTsMS), which accompanied corresponding MRI data brain spinal cord (presence new lesions). Previously, were no studies quality life (QoL) this subgroup world. Objective: to compare QoL indicators HAMS those healthy typical course relapsingremitting (RRMS). Patients methods. The study included on 518 14 regions Russian Federation for 2020–2021 years, whom was confirmed second examination. We used results analysis clinical neurologists questionnaires filled out HAMS. Two work – general (non-specific) Questionnaire assessing QoL, SF-36 (The MOS 36-item Short-Form Health Survey) special questionnaire MusiQoL (Multiple Quality Life). Results discussion. Almost all below control. When compared RRMS, pronounced decrease daily activity indicators, significant impact symptoms negative attitude towards healthcare system, low overall health index noted. Pearson correlation revealed stronger effect parameters frequency than RRMS. Conclusion. obtained indicate need management using second-line DMTsMS.